Indonesia Conference Directory

Endothelial Dysfunction is defined as an imbalance between coagulation and thrombosis factors, loss of vasodilatation response ability in endothelium-dependent stimuli, loss of bioavailability of NO, increase in vasoconstrictive agents, interference with inflammatory regulation, and stimulate the release of microparticles. This was could be a risk on cardiovascular disease in the future. The purpose of this study was to analyze endothelial dysfunction earlier by releasing micro particles as potential biomarker cardiovascular risk on children and adult. The method in this study was reviewing articles using micro particles to detect endothelial dysfunction. Many studies from articles found that CD 31+ as one of micro particles biomarker increased in endothelial dysfunction. Microparticles could be released from endothel when the endothel got activation or apoptosis, this was especially chronic inflammatory that could be found on children such as obstructive sleep apnea or on adults such as obesity and many hypoxia conditions. This hypoxia causes endothelial stress which in turn causes apoptosis that can be a danger signal of acute ischemia and the incidence of hypoxia and triggers tissue repair mechanism.