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Cocoa pod husk containing polyphenol compounds that have many beneficial activities for topical application. Phytosome is complex between water soluble phytoconstituent like polyphenol with phospholipid that known could enhance its oral and topical penetrations. The objective of this research is to determine the effect of phytosomal system to polyphenol skin penetration from topical serum preparation containing cocoa pod husk extract. Phytosome complex was made using thin layer hydration method at comparison of extract and phospolipid 1:1. The phytosome complex then developed to topical serum preparation. Skin penetration of polyphenol compounds were determined using franz diffusion cell. The results showed that phytosome system could enhance polyphenol skin penetration from the penetration that significantly different with non-phytosomal system (P<0.05).