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One of the dominant compound in a personal care product is sodium lauryl sulfate (SLS). This research was to study the effect of efficiency SLS on the removal of ammonium (NH4+) and COD on anaerobic batch reactors. In this reactors, septic tank sediments were contacted with artificial wastewater with an ammonium concentration of 30 mg NH4+-N /L and 300 mg/L COD concentration. Reactors were operated for 15 days with variations of SLS concentration 0.5, 10, 50, 100 mg/L. The best COD removal efficiency and the rate is in the 5 mg SLS/ L with the efficiency value of 99,6% and a reduced rate of 19,67 mg/L. The efficiency and rate of COD removal continued to decrease with increasing SLS concentrations. Meanwhile, the best ammonium (NH4+-N) removal efficiency and the rate was in the 0 mg SLS/ L with the efficiency value of 73.32% and a reduced price of 1.30 mg/L. The magnitude of the efficiency and removal rate of ammonium also decreases with increasing SLS concentration. Temperature and pH values for all reactors were in the range 26-28°C. The pH values in the five reactors were relatively the same both without and with the addition of SLS concentrations.