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Background: Anemia still becomes a problem worldwide, especially in developing countries. The World Health Organization (WHO) states that there are still more than 50 percent of women in the world suffering from anemia. In pregnant women the incidence of anemia can cause complications both for the mother and the fetus such as life-threatening bleeding, miscarriage, low birth weight (LBW) and premature birth. WHO defines anemia in pregnant women as a condition in which hemoglobin level is less than 11 mg / dL in the first and last trimester or 10.5 mg / dL in the second trimester or the hematocrit level is less than 37 percent. Purpose: The study aim to determine the effect of Fe tablets consumption on hemoglobin (Hb) level increase in pregnant women and to find out the factors related to the compliance of pregnant women taking Fe tablets. Method: This Systematic Literature Review employed Pubmed and Science direct database with a period of 2008-2018. The selection of articles was based on the inclusion and exclusion criteria. The Appraisal study employed The Joanna Briggs Institute Critical Appraisal Tools. Result: Consuming Fe tablets had an effect on increasing Hb levels of pregnant women. Pregnant women who got support from the people closest to them felt that they were appreciated, cared for and loved. Educational material about iron supplementation (Fe) should also emphasize on how to take Fe tablets properly and should give an understanding about the effects of anemia on mother and fetus. Health practitioners need to involve families in providing health education to increase support for pregnant women in taking Fe tablet. Conclusion: Iron supplement (Fe tablet) is effective for reducing anemia in pregnancy. Family and closest people-s support plays as an important role in increasing compliance in consuming Fe tablets.