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Academic performance has an essential impact in predicting the success of an educational program. This study was performed to identify the most influential factor in achieving the students academic performance in term of grade point average (GPA) and to identify the assessment method effectiveness. The cross-sectional study design was conducted to 158 medical students of Universitas Islam Bandung to participate in taking a quantitative survey. A questionnaire was adapted from student perception of assessment questionnaire (SPAQ). Data analysis used Chi-square test and ANOVA test with a 95% confidence interval and then proceeded with the Dunnett-s posthoc test. The majority of students have a good perception of assessment method (88.6%). From characteristic of the age, gender, admission test to medical faculty, and perception of assessment method, admission test through special interest and abilities became predictor factor that influencing the achievement of academic performance (GPA) with a p-value of 0.004 (p value> 0. 05). Admission test through special interest and ability (PMDK) highly influences the achievement of academic performance. The assessment system is quite effective in assessing the learning outcome. This is due to the perception of assessment method is more related to student approaches to learning than for achievement of academic performance