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The purpose of this study was to find out and explain the influence of e-learning model and interest to learn towards student learning ability. The research method used a survey method. The population in this study was 125 students of grade 10th, Aquino Amurang Catholic High School, with a total sample of 102 respondents (Isaac and Michaels table) through purposive sampling with data collection techniques through questionnaires with a Likert scale. The analysis used in this study was multiple regression analysis. The results lead to the following conclusions, first, student learning abilities can be formed by e-learning model and student learning interest; second, the influence of e-learning model and student learning interest provides a positive and significant influence on student learning abilities; third, both e-learning model and student learning interest have a positive and significant effect on students learning abilities.