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Disruption of functional activity is the biggest impact on stroke patients. To maintain, develop, restore motion, stimulate circulation, we need Range of Motion (ROM) and collaborate with Physiotherapists using Microwave Diathermy/Infra Red Ray. This study aims to determine the effect of Range of Motion (ROM) and Microwave Diathermy/Infra Red Ray on upper limb muscle strength in stroke patients in the neurology room of M.Natsir Regional Hospital in 2019.The study design was a Quasi One-Group Pre-Post Test Design experiment, the intervention was carried out for six days with a once-daily treatment Range of Motion (ROM) and Microwave Diathermy/Infra Red Ray therapy. The population in this study was a stroke patient of 40 respondents with a data collection method with purposive sampling, measurement of muscle strength before and after an intervention using a manual Muscle Testing instrument. Data analysis uses Paired t-test statistics. The results obtained, the age of the respondents ranged from 30-50 years, female sex, long suffered from 1-5 years of stroke. Paired t-test test results. Obtained Pvalue 0,000 with α = 0.05 (p <α) There is an influence between Range of Motion (ROM) and Microwave Diathermy/Infra Red Ray on muscle strength in stroke patients because each respondent experienced an increase in muscle strength scale after being given training and Microwave Diathermy/Infra Red Ray. Recommend the results of this study to conduct Range of Motion (ROM) and collaboration with physiotherapists using Microwave Diathermy/Infra Red Ray as a nursing intervention for stroke patients who experience weakness of the upper limb