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Abstrak This article aims to discuss the discourse of Islamization of science, not in the historical sense, but the development of a research program. Islamization is projected to build Islamic science in accordance with the lives of Muslims; requires tangible scientific or technological products. Therefore, the methodology of the Islamic scientific research program is an urgent need today. So that, efforts to find the methodology for Islamic research programs continue to be pursued; including by Adi Setia and Mohamad Muslih by borrowing the theory of the Methodology of Scientific Research Programes Imre Lakatos (w.1974); despite succeeding in stringing the steps of Islamization; but the application has not been successful in a concrete simulation. Therefore, this paper is concerned with simulating the Lakatosian Islamic science research program towards Islamization in the economic field, namely the meaning of welfare. This research a library and qualitative research; data were analyzed by contain interpretation, and critical analysis. As a finding, the Lakatosian Islamic science program was successfully simulated in the Islamization of the meaning of welfare. The implication is to strengthen the Lakatosian Islamic scientific research program as a method of research programs at Islamic Universities.