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Abstract Objective: The purpose of this study was to analyze the relationship between the practice of safe injections and the incidence of NSIs. Method: This study used observational analytic with a cross-sectional approach with a sample of 45 people taken by proportional random sampling using, data analysis used the chi-square test. The population in this study were all nurses in the inpatient ward of the hospital with a total sample of 45 respondents taken by proportional random sampling. Processing and data analysis techniques were carried out by the chi-square test. Result: The results showed that there was a relationship between safe injections practices with the incidence of NSIs. Conclusion: The study concluded that the lower the application of safe injecting practices, the higher the chance of the occurrence of needle puncture injuries. It is recommended that the Hospital can provide socialization about safe injections to the implementing nurses and take action according to the SPO and the existence of training and supervision from superiors on an ongoing basis.