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Higher education as an institution where its activities cannot be separated from environmental influences. In the 2000s the world was struck by the revolutionary attack of industrial 4.0 that runs smoothly but has a massive impact. The industry revolution 4.0 not only has changed the way business was done, but also significantly changed the culture, mind-set, behaviour and employment. The dramatic change that shook this establishment was called the disruption era. This paper is aimed at contributing to the strategic steps in dealing with the disruption era in the 4.0 industry revolution. The method used is the literature or media review, then performed a deep analysis and elaboration. The conclusions of this paper are: universities should implement appropriate strategies to face the industrial revolution 4.0. These strategies include: MOOC (Massive Open Online Course), and AI (Artificial Intelligence). The shift in the role of lecturers is more to teach the values of ethics, culture, wisdom, experience to social empathy because the machine is unable to do so. This is very important for the future of education is getting excellent.