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ABSTRACT Background: Anxiety is one of the problems that are often found in Emergency Department patients. Seeing the Emergency Department condition which is uncertain, in the terms of hustle and bustle of the room, worry of other patients, panic from the family, greatly affect the patients psychology. It makes difficult to concentrate. Therefore, research is needed to determine the effect of oral dhikr on decreasing scores of patients anxiety in Emergency Department. Objective: This study aims to determine the effect of oral dhikr on the decrease in anxiety scores of patients in Emergency Department. Method: This study used quasi-experiment method with pre and post test with control group design. The researcher used purposive sampling. The number of samples in experimental group and control group were 19 respondents respectively. VAS-A is used as an instrument in measuring anxiety levels. Data analysis used Paired T-Test and Independent T-Test. Results: The average of anxiety scores on experimental groups change from 62,74 to 44,47 meanwhile control groups change from 58,63 to 40,95. The result of Paired T-Test p < 0.05, which means that there are significant differences before and after the action at both groups in anxiety scores. While the result of Independent T-Test p > 0.05 showed that there is no difference in a significant decrease in anxiety scores between both groups. Conclusion: There is an effect of oral dhikr on the decrease in anxiety scores of patients in Emergency Department. However, there was no significant difference on the decrease in anxiety scores that was between the experimental groups and the control group.