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The objective of this study was to produce learning material of integer and fractions based on interactive multimedia with Islamic values that valid and practical. The type of this research was Research and Development (R & D). The model used 4D (Define, Design, Development, and Disseminate). The research subjects were 10 students of Junior high school of Muhammadiyah 1 Metro. The instruments used expert validation assessment questionnaires to determine the feasibility of the product and questionnaire responses of students to find out the practicality of the product. The results of the percentage analysis of expert validation were obtained on average, that is, 83.54% with very feasible categories. As for the results of the students response trials, the average percentage was 87.41% with a very practical category. Therefore, it can be concluded that learning material of integer and fractions based on interactive multimedia with Islamic values were very valid and practically used for learning.