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Most free drugs are characterized by high liposolubility, but they often have limited clinical applications because of poor dissolution and poor bioavailability. The purpose of present study was to evaluate commercial preparations of Acetaminophen tablets with respect to drug release, Pharmaceutical formulations often require additional materials (excipients) in addition to the active ingredient itself. The use of excipients in tablet formulations is expected to produce a quality tablet of Acetaminophen which meets the requirements of the physical properties of tablets and is able to provide good drug release. The result showed that commercial preparations of Acetaminophen vary widely in their dissolution behavior in dissolution run experimentation. Identifying this behavior of the products was essential as an in vitro tool for screening a good and a bad formulation. Parameter test drug levels observed were dissolved at t = 30 min (C30) with default parameters standard C 30 shows the results should not be less than 80% of drug levels. The different dissolution profiles of 8 samples were showing the results of dissolution with C30 are eligible (> 80%).