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Sepsis cause damage for cell, organ damage, decreasing of body weight, behavioral phenotype regression and will end in the death of most of victims. Extract of cogon grass root (Imperata cylindrica L.) acts as antioxidant in sepsis. This study purpose was to observe the effect of giving ethanol extract of cogon grass root to Body Weight and behavioral phenotype of septic mice model. This was an invivo study with randomized post-test controlled group design. We used 4 (four) groups of male mice (Mus musculus) DDY strains. Group 1 as the negative control, group 2 as the positive control, Group 3 and 4 treated ethanol extract of cogon grass root (90 mg/kg BB, and a dose of 115 mg/kg BB, respectively). This treatment was performed for 2 weeks. Every week we measured body weight twice a day. After 2 weeks, group 2, group 3 and 4 were injected lipopolysacharide for 8 hours to induce septic. Then we measured body weight and behavioral phenotype. The results showed no differences in body weight were found in the treatment group compared with control, suggesting no effect of ethanol extract of cogon grass root in decreasing mice body weight. Next, the behavioral phenotype observation showed, in group 2, most of the mice shown no activity, the mice were stationary, this contrary to other groups. The conclusion of the study is the treatment of Ethanol Extract Of Cogon Grass Caused No harm for Body Weight and behavioral phenotype of septic mice model.