Indonesia Conference Directory

Background: Allergy is a hypersensitivity induced by exposure to certain antigens that cause dangerous immunology reactions on the next exposure. There is a new innovation as antiallergy, one of them is apple because it contains quercetin. Quercetin are believed to have an influential effect on human health, that of antiallergy and anti-inflammatory activity. Mast cells are part of the connective tissue that has the pseudopod to mobilize one to lung tissue. Objective: To determine the effectiveness of Malang Apple Cider (Malus sylvestris) on decreasing the number of mast cells in the lung of an allergic induced rat. Method: Experimental research using Post Test Control Group Design. Samples were white male Wistar strain rats which were divided into 5 groups, each group contains 5 rats. The positive control group was induced with ovalbumin through intraperitoneal and inhalation. Besides ovalbumin induction, treatment groups were also given apple cider with doses of 15%, 20%, and 25%. Lung tissue was taken and then paraffin blocks were created and stained using Methylene blue staining and evaluated with the microscope in 40 x magnification. Data was analyzed using One Way Anova. Results and discussion: Statistical results showed there were no significant (p = 0,079 > or p 0.05). This decline is due to the levels of Quercetin in apple cider can prevent Unfortunate degranulasi cell mast. However, the decrease was not significant occurs due to several factors, including the strength of apple cider, the absorption in the intestine, stress factors, and environmental circumstances. Conclusion: the unfortunate Apple Cider (Malus sylvestris) were not effective in decreased the number of mast cells in the rat lung induced allergen.