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Background: The concept of quality of life has been widely used in various fields, especially health and nursing. A discussion of the concept of quality of life is an important consideration for evaluating the end results of health services provided by health workers as in the case of cardiac surgery, hence the concept of quality of life in cardiac surgery patients requires a specific definition. Various experts have defined the concept of quality of life. However until now there has not been an agreement on appropriate and specific definitions Aim: To present a concept analysis of quality of life from the perspective of cardiac surgery Design: The method used in this paper was the approach of Walker & Avant (2011) Data Sources: This concept analysis was carried out with the aid of literature on quality of life obtained through the internet databases of CINAHL, Proquest, and Google Scholar. The key words of interest were “Quality of Life” and “Cardiac Surgery.” The search timeline was adjusted to articles published within 2009 to 2019. Review Method: This concept analysis was performed using the 8-step method Proposed by Walker and Avant. Results: Following the Walker and Avant-s method, identification of the attributes, antecedents and consequences of quality of life led to an operational definition of the concept of quality of life as the individuals perception of himself subjectively related to physical, psychological and social behavior to be prosperous in his life Conclusion: This concept analysis was able to show that, quality of life is the individuals perception of himself subjectively related to physical, psychological and social behavior to be prosperous in his life. Quality of life will provide benefits to cardiac surgery patients: reduce length of stay and maintenance costs, prevent complications and social isolation