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A massive change in the progress of information technology becomes a challenge in the learning strategy. Teaching and learning chemistry required to adaptat with the latest technology in maximizing learning activities. Thus the learning process must be improved through the application of innovative learning material that can encourage the students to learn actively, be more meaningful, and motivate the learner to learn optimally to achieve their competencies according to the national curriculum oriented towards the Indonesian National Qualification Framework (KKNI). This study aims to innovate project-based learning to support blended learning in accordance with the demands of an KKNI-oriented curriculum for in Analytical Chemistry. The research was conducted at Universitas Negeri Medan at accademic year 2019/2020. The study are consisted of (1) the development of project-based learning package on Distillation topic, (2) integration of information technology, multimedia and the web into the learning learning package for delivering the subject face-to-face learning, independent learning and blended learning, (3) standardizing and evaluating of learning packages, and (4) implementation of an innovative learning material in the teaching of Distillation topic. The results show that innovative project-based learning integrated with blended learning has been successfully developed to be used to improve academic activities in the teaching of Distillation topic. The implementation of innovative project-based has been used for face-to-face teaching and blended learning in the experimental group compared to the control group using conventional learning. The results has convinced that an increase in student competence has been achieved in experimental class because an innovative learning model can attract students attention to learn independently. The learning facilities provided in the learning package has been proven to guide the students for active learning to studey analytical separation. The students that are treated with project-based learning in experimental class are having optimun in their learning potential, and results in achieving their competence as required by KKNI curriculum.