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Abstract Objective: The aim of this study was to determine the effectiveness of topically administered corn silk extract to reduce inflammation degree in periodontitis. Methods: Material used in this research was 40 days old corn silk extract. Twelve male Wistar rats (Rattus novergicus) with the initial weight of 150 gram were used as experimental model animals. The rats were then divided into four groups with 3 rats each. The animals were induced with 5-O silk ligature wire for seven days. After that the silk ligatures were removed and each group were given treatments according to their group for seven days. Results: F3 shown the best anti-inflammation effect with mild inflammation in each sample (p<0.05). Whereas in F1 and F2 each sample had moderate inflammation (F1, F2: p>0.05). Conclusion: Topically administered corn silk extract (Zea mays. l.) are effective to reduce the degree of inflammation in periodontitis.