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Background: Globally 34 million people are living with HIV-AIDS (Human Immunodeficiency Virus Acquired Immuno Deficiency Syndrome) and 23.5 million live in sub-Saharan Africa. Increased prevalence of HIV to decreased dramatically in Penderia AIDS deaths by 32%, demographics or the environment, the change of status of HIV positive and HIV negative into economic and social challenges of being diagnosed with HIV. Transformation conditions become chronic HIV patients can be treated by increasing the effectiveness of immunology treatment with health-related quality of life programs or called Health releated Quality of Life (HRQOL). The purpose of this study is to review the factors that affect the quality of life of people living with HIV in the health sphere. Method: Studies apprasial program uses Critical Appraisal Skills Program (CASP), and methods of synthesis using a modification PEOS data sources available from PubMed, Medline, and ProQuest. Results: Results and discussion journals give a very big that in developed countries the level of religious people living with HIV are very powerful effect on the adherence of HIV to ARVs (Anti Retro Virus) and people living with HIV can coping health problems with both, particularly the psychosocial issues that affect the role of people living with HIV itself, in contrast to the level of religious people living with HIV in developing countries, they tend to be less in the exercise of religious or spiritual impact on fear, not trust or bad stigma from society and tend to be non compliant in taking ARVs. Conclusion: HRQOL in people with HIV-AIDS affects 50% of physical health, psychosocial health 30%, 20% mental-emotional and spiritual or religious.