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Abstract Objective: This study aimed to determine the description of the incidence of insulin resistance (IR) in pregnant women in maternal and child hospital Khadijah Makassar. Method: This research was a cross-sectional study, a research site at the Polyclinic of Khadijah Mother and Child Hospital, which was conducted from February 2019 to April 2019. The sample of the study were 87 pregnant women, insulin resistance calculated based on the HOMA-IR index = fasting blood glucose (mg/dl) x Fasting insulin (mú/ mL)/ 405. HOMA-IR index was divided into 3 tertiles, namely tertile 1 (3.10-5.84), tertile 2 (5.85-8.62), and tertile 3 (8.63-35.26), categorized as insulin resistance if HOMA-IR was in tertile 3. Result: Respondents in this study were mostly aged <35 years, i.e., 71 (81.6 %) with the majority of gestational age already in the 3rd semester and nutritional status as measured by the upper arm circumference was also the normal, and ethnic was Makassar The number who experienced insulin resistance, i.e., 29 people (33.3%) of 87 respondents. There were no differences in HOMA-IR between all groups, but in table 2 it was seen that mothers who had insulin resistance were those under 35 years old, trimester 3, primigravida, normal nutritional status and Makassar ethnic Conclusion: Mothers who had insulin resistance were those under 35 years old, trimester 3, primigravida, normal nutritional status, and Makassar tribe.