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Abstract Objective: This study aimed to compare CRP between mother with PROM and mother with prolonged labor. Methods: It was a Cross-Sectional Study and sampling technique used was consecutive sampling, sample size was 50 mothers, consist of 25 PROM mothers and 25 prolonged labor mothers. Inclusion criteria were pregnant women over 37 weeks with PROM or prolonged labor, not suffering from HIV/AIDS, Hepatitis B, preeclampsia, eclampsia, kidney and diabetes mellitus. Blood was collected in both groups through vein. The blood was centrifuged to obtain serum and CRP was examined by the ELISA method in the laboratory of the Hasanuddin University Makassar. Data analyzed using Chi-square and independent T-test. Results: The mean CRP level of maternal with PROM was 11.00 mg/l while the mean CRP protein level in prolonged labor was 16.00 mg/l. Maternal CRP levels with prolonged labor are higher at 5.00 mg/l compared to CRP PROM levels and it is statistically significant (p = 0.002, p <0.05). Conclusion: CRP levels of prolonged labor is higher compared to CRP PROM levels.