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Abstract. The community has the right to get quality and affordable health services. One effort to realize quality health services is managing of patient data, by utilizing information technology. Doctor-s Office Quality-Information Technology (DOQ-IT) application is an electronic medical record application that resides on a doctors personal computer. This application include clinical decision support system to increasing patient safety. The purpose of this study is to develop a Doctor-s Office Quality-Information Technology (DOQ-IT) Application to Improve Patient Safety. Aplication development used waterfall methode. DOQ-IT application has clinical decision support system in the form of Determination of nutritional status, blood pressure, family history of a disease such as Diabetes, stroke and includes the reaction of drug content to the patients allergic history. So that, the DOQ IT application can improve the quality and safety of patients.