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ABSTRACT Abstract Exploration of several usage of medicinal plants could support the preservation and sustainable utility of these crops. Some research results shown that bitter leaf plant (Vernonia amygdalina) could be used as medicinal herb and or botanical insecticide as well. Several workers have demonstrated the possible application of powder or extracts from bitter leaf plant materials to control storage pests Callosobruchus maculatus (stored cowpea bruchid) dan Sitophilus zeamais (the maize weevil). There was no progeny development of the bruchid in samples treated with bitter leaf powder. The leaf powder was mixed with cowpea seeds, to prevent oviposition and hatching of the eggs, and adult emergence of bruchid, even caused 100% mortality of adult cowpea bruchid after 72 hours of exposure, thereby helping in their management. The effectiveness of V. amygdalina in the control of S. zeamais causing also 100% mortality. Other essential oil of V. amygdalina (0.3%) was able to protect maize from the maize weevil by evoking a high repellant action against weevil, then reducing the number of weevil progeny production, without damaging the grain. The main insecticidal properties of V. amygdalina were identified as chemical compounds like sesquiterpene lactones containing vernodalin, vernodalol and 11, 13-dihydrovernodalin, which act as an insect feeding deterrent. All the tested plant parts powders were toxic, however the leaf powder was more toxic to cowpea bruchid. Its possible application in Indonesia in controlling the storage pests, were needed to be evaluated to support the efficient and eco-friendly plant pest and disease control program. ABSTRAK Abstrak Penggalian berbagai macam pemanfaatan tanaman obat dapat menunjang usaha pelestarian dan pemanfaatan berkelanjutan tumbuhan obat tersebut. Berbagai hasil penelitian menunjukkan, bahwa selain sebagai tanaman obat, tanaman daun afrika (Vernonia amygdalina) dapat pula dimanfaatkan sebagai insektisida nabati. Beberapa peneliti telah mendemonstrasikan kemungkinan aplikasi tepung atau ekstrak dari bahan tanaman daun afrika dalam pengendalian hama gudang Callosobruchus maculatus (kumbang kacang tunggak/merah) dan Sitophilus zeamais (kumbang biji jagung). Pada sampel kacang yang diperlakukan dengan tepung daun afrika, tidak terlihat adanya perkembangan populasi kumbang kacang. Tepung daun afrika yang dicampur dengan biji kacang, mencegah peletakan telur dan penetasan telur, sehingga menekan munculnya/ lahirnya kumbang dewasa, bahkan dapat menyebabkan 100% mortalitas kumbang dewasa setelah perkauan selama 72 jam.. Demikian pula pada pengendalian kumbang jagung S. zeamais, tepung daun afrika menyebabkan 100% mortalitas kumbang jagung dewasa. Hasil penelitian menunjukkan bahwa minyak atsiri daun afrika memberikan efek penolakan makan terhadap kumbang jagung sehingga menekan jumlah produksi keturunan kumbang dewasa, tanpa menyebabkan kerusakan pada biji jagung. Bahan insektisida