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Quality of care in hospitals could be improved if it is supported by an increase in physical facilities. The installation of room is one manifestation of the physical facilities that are important for the care and safety of patients because of direct structuring patient room can affect the psychological, comfort, security and safety of patients. The purpose of this study was to determine spatial relationship with the installation of patient safety in Muhammadiyah Hospital of Lamongan and Siti Khodijah Hospital in Sepanjang The study design used is cross sectional correlational analytical method, the sample size in this study as many as 11 rooms in Muhammadiyah Hospital of Lamongan and Siti Khodijah Hospital in Sepanjang with sampling technique used was total sampling. The instrument used was a questionnaire. Presentation of data used pie charts and tabulation as well as using Spearmans rho. The results of the study with a questionnaire on spatial inpatient showed the results of 9 rooms (82%) according to the standard, 2 rooms (18%) did not meet the standards, while based on the results of questionnaires patient safety showed 10 rooms (91%) good and 1 room (9%) was not good. The results of test analysis Spearmans Rho get no significant relationship between spatial inpatient with patient safety (ρ = 0.026 <α 0.005). Layout suitable standards and meet the needs of patients could assure and improve the quality of services as well as increased patient safety (patient safety).