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Physical activity increases formation of oxidant compounds. The formation of oxidants can trigger oxidative stress, a condition caused by the imbalance between the production of free radicals and the antioxidants. Malondialdehyde (MDA) is one of the biological markers of oxidative stress in organism. Oxidative stress can be prevented by giving exogenous antioxidants. Coconut sugar is a rich source of antioxidants. This study aims to determine the effect of coconut sugar towards the levels of plasma MDA after submaximal physical activity. The study was an experimental laboratory with the pretest-posttest control group design and which was conducted in 7 days. The sample of this study used 30 human subjects aged 18 to 20 years. The results showed that the mean plasma MDA levels K0, K1 and K2 were significant. The decrease in plasma MDA levels in K1 was 19.15% and K2 was 37.42%. The giving of coconut sugar can inhibit plasma MDA levels after submaximal physical activity.