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The most widely used contraceptive method in Indonesia is hormonal contraception with injection types. Depo Medroxy Progesterone Acetate (DMPA) is a type of injection contraception that is widely used, ordinary people know it as a 3-month birth control injection. The 3-month injection contraception has advantages and disadvantages. One side effect of progesterone hormone content in the cardiovascular system can lead to the increased of bloodpressure. This study aims to determine the relationship between the duration of 3-month injection contraception usage and the incidence of hypertension in mothers of Dukuh Village, Bayat District, Klaten Regency. This study uses a descriptive correlational design with a cross sectional approach . Probability sampling was used as a sampling technique with a simple random sampling method with a total sample of 52 respondents. The statistical test used was kendall tau. The research results obtained p value 0.00 ( p value <0.05), so it can be concluded that there is a relationship between the duration of 3-month injection contraception usage and the incidence of hypertension in mothers of Dukuh Village, Bayat District, Klaten Regency.