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The objectives of this research are : Knowing how the science process skills of students based on gender, based on schools location the human respiration system topic on grade XII Science SMA Negeri in Langsa city. The type of this research is descriptive quantitative, research observed 150 respondents of class five grade student from Senior high schools in Langsa city-aceh. The data collecting was done by using essay test of science process skill of student.The result : The science process skills with score 75,41%, based on gender, at the female students is 74,55% and male students is 71,59%, based on schools location which in town area is 75,16% and in village area is 72,32% (good cattegory) of students at the human respiration system topic on grade XII science SMA Negeri in Langsa City-aceh.