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Background: Most toxic substances in the body are metabolized in the liver, so its giving a hepatotoxic effect. This study aimed to examine the effects of consumption of date seeds in the liver protection. Method: This reserach uses a systematic review design. Articles search is systematically carried out on the relevant publication databases such as Google scholar, PubMed and DOAJ. The keywords used are "hepatoprotective", "date seed", and "date pits". Publication articles are limited between 2014-2019. All aplicable studies were evaluated based on titles and abstracts, then continued to the content. Results: we found 44 data sets of a total of 218 articles identified. Based on the inclusion criteria and critical assessment of the article, only 10 articles are in accordance with this review. Conclusion: Date seeds contain antioxidants that significantly increase antioxidant activity, reduce free radicals and improve liver enzimes and tissues.