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Background: Incident of Patient Safety is a significant cause of patient morbidity in hospital. In general reporting system of Incident of patient safety in this hospital is not good enough, indicate by no data reporting related to incident of patient safety. In fact, is too much complaint related to unsafe care, especially for patient fall, infection and medication error. The purposed of this study is to investigate “Factors Contributing to patient safety Incident within implementing patient safety goals. Method: This study used descriptive and analytical design with a cross sectional approach, and concurrent mix quantitative and qualitative method by open question, to completely information is needed. The population of this research are nurses, who work on inpatient setting with 94 sample sizes. The quantitative data collection analyzes by Univariate, Bivariate and Multivariate, while qualitative data, analyze by content analysis. Result: the prevalence of incident of patient safety was high rate, the chart review study found that incident of patient safety in Depok City Hospital is 47.9%, while confirm by content analysis data is higher up to 64.8%. Moreover, factor that contribute to incident of patient safety are: staff factor, Task Factor, Communication factor and medical equipment factor is the mean factor with (PV <0.05). While Work Environment factor, Organization factor, Training and Education factor, and team factor are not contributing to incident of patient safety. Conclusion: Prevalence of incident of patient safety is the high rate. Factor that contribute to incident of patient safety in this hospital are: Staff factor, Task factor, Communication factor and medical Equipment factor.