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Background: Wounds are injuries to parts of the body, when the skin and underlying tissue lose their tissue continuity. Antimicrobial preparation such as povidine iodine is commonly used to reduce the risk of infection in minor injuries, but it can cause side effects. Lemongrass is one of the grass plants often used as a medicine. It has broad indications as analgesic, antiseptic, antiemetic, antitussive, antirheumatic, and anticonvulsant. Lemongrass is also used as an antibacterial, anti-inflammatory, and antioxidants that can affect the wound healing process. Purpose: This study aims to determine the effectiveness of lemongrass extract (Cymbopogon citratus) 30%, 60 and 80% compared with negative control and positive control group on incised wound healing in white mice. Methods: This study is a true experimental research with post-test only control group design using complete randomized. This research used 25 white mice divided into 5 groups: 30% lemongrass extract, 60% lemongrass extract, 80% lemongrass extract, negative control (Aquades) and positive control (Bioplacenton). Result: Analysis of Shapiro Wilk normality test data show p value > 0.05. Levenes Test homogeneity test was obtained p = 0.730 (p> 0.05), it showed that homogeneous data. Based on One Way ANOVA test showed result with p value > 0.05 (0.881). It means no difference the healing of incision wound. But for the average wound healing time it is known that lemongrass extract 60% is more effective in healing wounds in white mice compared to the concentration of lemongrass extract 30% and 80%, where total wound healing occurred on day 14 in the 60% lemongrass extract. Conclusion: There is no difference in effectiveness of lemongrass extract (Cymbopogon citratus) 30%, 60% and 80% compared with negative control groups and positive control on incision wound healing in white mice.