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INTRODUCTION Karika (Carica pubescens) have a kinship related to papaya (Carica papaya). Karika contains various nutrients such as vitamins, minerals, and active substances that can be used for skin care, such as papaya. That karika content can be applied to bath soap products. The purpose of this research was to determine the inhibition of karika soap to the growth of Staphylococcus epidermidis bacteria. The method used in this study was agar diffusion. Samples in this research were 12 karika soaps with different formulation (variations in karika concentration and NaOH concentration). A positive control using papaya soap that has been circulating on the market. The results of the study were analyzed using ANOVA with a confidence interval of 5%. The results showed that the significance value was 0.472> 0.05 so there was no significant difference between the soap formulations on the inhibition zone of the Staphylococcus epidermidis bacteria. RESULTS AND DISCUSSION The results of the study were analyzed using ANOVA with a confidence interval of 5%. The results showed that the significance value was 0.472> 0.05 so there was no significant difference between the soap formulations on the inhibition zone of the Staphylococcus epidermidis bacteria. The highest inhibitory zone is in soap with formula 1 (1.38 cm), the lowest inhibitory zone is in soap with formula 7 (1.1 cm), while the papaya soap inhibition zone (positive control) is 1.7 cm. Suggestion from this research is to reformulate karika soap to improve its quality. Keywords: Karika, Soap, Staphylococcus epidermidis. References 1. Betsy, K. J., Mary Jilu, Reshma Fathima and Jaya T. Varkey. 2013. Determination of Alkali Content & Total Fatty Matter in Cleansing Agents. Asian Journal of Science and Applied Technology ISSN 2249 - 0698 Vol. 2 No. 1, 2013, pp.8-12. © The Research Publication, www.trp.org.in. 2. Budi, Eko M. 2015. Skrining Fitokimia Dan Kandungan Total Flavanoid Pada Buah Carica Pubescens Lenne & k. Koch di Kawasan Bromo, Cangar, dan Dataran Tinggi Dieng. Skrining Fitokimia (73-82), Jurnal El-Hayah Vol. 5, No.2 Maret 2015. 3. Domingues, Gabriel., & Matt Schul. 2014. Soap Lab. ADM Biorenewables Education Laboratory Soap Lab Summer Academy. (online) (http://www.engineering.iastate.edu/brl/files/2011/10/brl_soaplab.pdf), diakses pada 15 September 2019. 4. Dunn, Kevin M. 2010. Scientific Soapmaking (The ChemistryOf The Cold Process). Farmville, VA: Clavicula Press. 5. Hidayat S. 2000. Potensi dan prospek pepaya gunung (Carica pubescens Lanne & K. Koch) dari Sikunang, Pegunungan Dieng, Wonosobo. Di dalam Seminar Sehari Menggali Potensi dan Meningkatkan Prospek Tanaman Hortikultura Menjadi Ketahanan Pangan dalam rangka Hari Cinta Puspa dan Satwa Nasional. Prosiding seminar; Bogor, 5 November 2000. Bogor: UPT Balai Pengembangan Kebun Raya LIPI Bogor. hlm 89-95. 6. Kenna. 2016. Understanding Water Discounts And Lye Solution In Soapmaking. (online)(