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Abstract Purpose: this study aims to assess the correlation of vitamin B12 level with insulin resistance towards the outcome of the baby and the placenta. Method: This study used a prospective cohort study design. Total sampling was 87 people. The samples are pregnant women trimester II and trimester III. Data were analyzed using the Chi-square test and the Spearman test. The result of this study shows that there is no significant correlation between levels of vitamin B12 and insulin resistance with a value of ρ 0.864> 0.05, there is no significant correlation between vitamin B12 and infant weight with a value of ρ 0.107> 0.05, there is no significant correlation between vitamin B12 and placental weight with a value of ρ 0.107> 0.05. There is no significant correlation between insulin resistance and infant weight with ρ 0.845> 0.05 and there is no significant correlation between insulin resistance and placental weight with ρ 0.845> 0.05. So it can be concluded that there is no correlation of vitamin B12 with insulin resistance towards the outcome of the baby and the placenta.