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Scabies is the most common skin disease, which mostly occurs in developing countries. In Indonesia, out of 12 most common skin diseases in Indonesia, scabies is ranked third. Identical scabies disease with diseases that occur in santri in Islamic Boarding Schools, with the incidence of scabies in Islamic Boarding Schools that vary between 13.48% -89.9% and 4.6−12.95%. The level of knowledge and awareness to behave in a clean and healthy life (PHBS) is one of the factors that cause scabies. Based on that this study aims to make a practical module in the form of a "Healthy Santri Pocket Book" containing material about personal hy-giene and scabies to reduce the incidence of scabies in Manarul Huda Islamic Boarding School Bandung as an innovation free scabies boarding school which is expected to become a role model " West Java Islamic Boarding School Healthy, Free of Scabies ". This study is an observational analytic study with a cross-sectional approach. This study aims to assess the knowledge and its effect on the incidence of scabies in santri before and after being given a "Healthy Santri Pocket Book". Pre-test and post-test contain questions about personal hygiene (PHBS) and scabies that are in accordance with the material contained in a healthy santri pocket book. Santri respondents in Manarul Huda Islamic Boarding School in Bandung who were af-fected by scabies before being given the "Healthy Santri Pocket Book" were 27 respondents (81.8%) and af-ter being given "Healthy Santri Pocket Book" there was a decrease in the incidence of scabies to 15 respond-ents (45.4%). In the research results found the pre-test results were 86.67. There was an increase after being given a healthy santri pocket book to 94.8. Based on the results of statistical analysis it can be seen that p <0.05 (P = 0.008) which means that there is an influence on the provision of PHBS material by giving a healthy santri pocket book statistically.