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Background : Chronic renal disease is a chronic pathological process in renal that accompanied by a progressive decline in renal function and generally ends up as renal failure. Chronic inflammation and oxidative stress are key factors in progression. Black cumin extract has antioxidant and anti-inflammatory effects that is thought to repair renal tubular and inhibit progression of the damage. Objective: to evaluate the improvement of renal proximal tubules in rat with CCl4-induced chronic renal damage after black cumin extract administration. Method: Thirthy rats were divided into five groups; normal, CCl4-induced control and CCl4-induced treated with black cumin in dose 1.2 ; 2,4; 4.8 g / kgBB. Chronic renal damage induced by CCl4 i.p @ 1mL/kgBB for 8 weeks, three times in week. After CCl4 induction, administrated black cumin extract by daily intragastric gayage for 4 weeks. At the end of the study, the animal sacrificed and tissue sample were obtained. The renal was examined histologically by routine H&E staining and the amount of hyaline cast in the proximal tubule is calculated. Results and Discussions: The result showed that the amount of hyaline cast in the proximal tubule significantly decreased after black cumin extract adminstration. Conclusion: Black cumin extract decreases the amount of hyaline cast in the proximal tubule. The antioxidant and anti-inflammatory effects of Black cumin extract may modulate the improvement renal tubular.