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Purpose: This study was to determine the risk factors for HIV incidence in MSM communities (Men Sex with Men) at the HIV / AIDS Advocacy Institute in Southeast Sulawesi. Methods: use analytic surveys and case control. Data collected includes age, education level, occupation, gender, and sexual behavior including (condom use, cleaning reproductive organs, using basic materials (lubricants, silicon, water), changing partners, buying sex from men, buying sex from women, sell sex to men, sell sex to women, oral and anal sex. Instrument used secondary data and primary data. The number of samples in this study were 40 respondents consisting of 24 cases and 24 controls. Data is collected in two months with the team. Results: The results showed that the risk factors for HIV incidence in MSM communities were sexual behavior (p = 0.009, OR 5.898 and 95% CI 1,609-20,479), while injecting drug use factors were not a risk factor for HIV incidence in MSM communities (p = 1,000, OR 1.571 and 95% CI 0.238-10,365). Conclusion: The Southeast Sulawesi HIV/AIDS Advocacy Agency is increasing information and education (IEC) to MSM communities, developing and finding HIV cases, especially in key populations.