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Abstract Objective: This research was aimed to observe the hard and soft tissue lesion in the oral cavity assessed with the periapical and panoramic radiographic examination in Dental Hospital of Hasanuddin University. Methods: It was an observational descriptive study with cross-sectional design through periapical and panoramic data from April – May 2017. The results were presented in the distribution table and graphic. Results: To diagnose almost various oral cavity lesions, the dentist need to receipt a radiographic examination both intraoral and extraoral radiography. The most common hard tissue lesions that detected through periapical radiographic were caries 37.1%, pulp lesion 34.6% and periodontal lesion 17.9%. In panoramic radiographic data, the highest prevalence of tissue lesion was periodontal lesion and periapical abnormality 33.7% with the number of women was higher than men in the 12-25 year age group. Conclusion: The prevalence of hard and soft tissue lesion in the oral cavity was high.