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ABSTRACT Background: In the current global era, a health worker is demanded to provide a good quality of health services. Good quality services can be obtained through good collaboration among medical workers such as medical doctors, nurses, and pharmacists as teamwork. One effort to realize effective collaboration among health workers is early collaboration during the learning process, namely, conduct joint training among health-majoring students using Interprofessional Education Strategy. The aim of this systematic literature review is to conclude and to examine the literature in the effectiveness model of interprofessional education (IPE). Methodology: the stages of the systematic literature review that are used namely: identifying problems, determining priority problems, determining research questions, determining framework (PEOS), critical appraisal, data extraction, and mapping. Examination for relevant literature are taken from three main databases namely (Pubmed, One Search and Science Direct) Results: A total of 17 publication journals are fulfilled to the inclusion criteria. Thematic analysis is carried out to identify the main points. The researcher classifies the main points, namely the model in interprofessional education and effectiveness in inter-professional education. Conclusion: Several models in IPE that can significantly improve interprofessional collaborative performance among the participants. Additional provision for the inclusion of initial IPE, simulations, and workshops in health professional education can generally encourage better communication and collaboration between health professional students. Interprofessional education leads to increased attitudes towards interprofessional teams and inter-professional learning, as well as abilities in interprofessional teams, and confidence, knowledge, and ability to manage people with long-term conditions. Demonstrate that the provision of interventions is proven directly and effectively contribute to the development of health professionals who are ready to collaborate with other health workers in order to improve service to the patients.