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ABSTRACT BACKGROUND Over the past 40 years there have been significant changes in the disease pattern around the world. Non-communicable diseases (NCDs) have replaced the earlier global threats to health such as undernourishment, malaria, HIV and TB. The major NCDs responsible for these deaths included cardiovascular diseases (17.9 million deaths); cancers (9 million deaths); chronic respiratory diseases (3.8 million deaths); and diabetes (1.6 million deaths). In Indonesia, 35% Cardiovascular diseases, 12% Cancers, 6% Chronic respiratory diseases, 6% Diabetes, 15% Other NCDs, 21% Communicable, maternal, perinatal and nutritional conditions, 6% Injuries. The global probability of dying from one of the four main NCDs in 2016 was 18%, with a slightly higher risk for males (22%) than for females (15%). The significance of gender equity and gender inequities for women-s health has been recognized internationally. Women are affected by NCDs in different ways to men. Not only are women-s experiences of NCDs influenced by the social conditions of women-s lives which are different to those of men, NCDs often manifest differently in women than they do in men. Moreover, women experience a higher burden from chronic disease and live more years of life with a disability from chronic disease then do men. In this study, we analyze the most common cause NCDs related to woman in outpatients internal medicine clinic patients at I Lagaligo Hospital, East Luwu, South Sulawesi. METHOD This study was held in February – June 2019. We collected all the new patients in outpatient internal medicine clinic. This study was a cross sectional study with descriptive analysis. RESULT In five months, we found 319 subjects with newly diagnosed as NCDs. 179 were women (56,1%). From these two groups, we found CVD as the highest NCDs (93 cases in women and 40 cases in men). If we focused on the women group, based on age, in 15-29 and 30-49 years old, thyroid disease as the highest NCDs. In 50-59, 60-69, and more than 70 years old, CVD as the highest. CONCLUSION The most common newly diagnose with NCDs in woman is differed based on age stage, in the younger age group, dominated with thyroid disease, meanwhile in the older group, CVD as the most of NCD. KEY WORDS: Non-Communicable Diseases, woman, I Lagaligo