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This study aimed to analyze the effect of guided inquiry learning model on science process skills and cognitive ability of elementary school students. The population of this research is all of fifth grade student in SDN 106205 Pasar Baru, that divided into two class, in second semester of academic year 2018/2019. Sampling technique of this research is total sampling, Class VA was control class taught by conventional learning and class VB was experimental class taught by guided inquiry model. This research was quasi experimental with two group pretest-posttest design The instrument of this research were valid test that contain 20 items multiple choice of science process skills and cognitive ability. The data were analyzed using t-test at the significance level 0,05. The result showed that students science process skills that taught by guided inquiry is better that students science process skills that taught by conventional learning.