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Background: Preeclampsia remains a burden in developing countries such as Indonesia. The precise mechanism of its pathogenesis is still debatable. Oxidative stress, inflammation and malnutrition have been proposed. Coenzyme Q10 (CoQ10) is a vital nutrient in pregnancy as it can increase other antioxidants level such as vitamin B, folic acid, and superoxide dismutase (SOD). Aim: This article aims to review the role of CoQ10 to other antioxidants, which are vitamin B, folic acid, and SOD in pregnancy, in correlation with oxidative stress. Methods: Few prior journals and research are reviewed for role of coenzyme Q10 in pregnancy, particularly in preventing preeclampsia. In order to function at its best, CoQ10 must work together with other micronutrients, for example vitamin B, folic acid, and SOD. This article focuses on CoQ10 and SOD. Discussion: CoQ10H2 or ubiquinol can prevent oxidative stress and vascular endothelial aging through mitochondrial function activation, reduction of intracellular reactive oxygen species (ROS), increase of nitrite oxide production and expression of endothelial nitrite oxide sintase. Meanwhile, SOD can change superoxide free radical into hydrogen peroxide (H2O2) or ordinary molecular oxygen (O2); several ions work on SOD include copper, zinc, iron, manganese, and nickel. Conclusions: Coenzyme Q10 must work in conjuction with other antioxidants, mainly SOD, or vice versa, in order to function at its best. Keywords: Coenzyme Q10; Indonesia; Nutrition; Antioxidants; Pregnancy.