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Abstract: Objective: This study aims to observe the effect of mangosteen skin extract on BAX expression. Methods: This experimental study was done in 30 mice randomly assigned to groups receiving different treatments. The control group received Dimethyl-Benz(a)anthracene (DMBA), a potent carcinogen, induction while the treatment groups received mangosteen skin extract with 100, 200, and 400 ppm concentrations. The BAX level from each mouse was assessed using ELISA. Result: BAX level in the treatment group was higher than the control group, except at the dose of 100 ppm. BAX level in mice treated with 200 ppm and 400 ppm was higher than the control group with the 200 ppm group showing a higher level. Conclusion: Mangosteen skin extract increased BAX level in DMBA-induced mice.