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ABSTRACT There are so many kinds of traditional medicinal plants that are used for the treatment of diabetes mellitus in Indonesia. For instance, agarwood leaves (Aquilaria Microcarpa Baill) and cinnamon bark (Cinnamomum Burmanii) are such two plants that still not publically known yet if both can be used for the treatment of diabetes mellitus.This study aimed to determine the effectiveness of a mixture of agarwood leaf infusion (Aquilaria Microcarpa Baill) and cinnamon bark(Cinnamomum Burmanii) in decreasing blood glucose levels in male galurwistar rats with hyperglycemia.This study applies an experimental method using 25 male galurwistar rats where each group consisting of 5 rats. There are five different treatments, such as negative control (Aqua PI), positive controls (Glibenclamide), and 3 control treatments of mixed doses of agarwood leaf infusion (Aquilaria Microcarpa Baill) and cinnamon (Cinnamomum Burmanii) with the concentrations as much as 1,5 ml/kgBB, 3 ml/kgBB, 6 ml/kgBB.This study was conducted within 14 days and the measurement of the blood sugar levels be done in the day-3 (H3), day-7 (H7), day-11 (H11) and day-14 (H14). Data found were analyzed statistically with the One Way ANOVA and showing a significant value (p <0.05) in lowering the blood glucose. The results shows that the most effective of mixed dose between agarwood infusion (Aquilaria Microcarpa Baill) and cinnamon bark (Cinnamomum Burmanii) among the three dosage concentrations is a dose of 6 mg/ kgBB.