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The availability of national medicines in Indonesia in the era of the national health insurance (JKN) has be-come a polemic that cannot be overcome instantly such as medicine shortage and overstock. This situation will affect patient safety and continuity of health service by provider. Various stakeholders play an important role in fulfilling national medicines needs, namely Ministry of Health, pharmaceutical industry, health facilities, and Social Insurance Administration Organization (BPJS). This research aims to determine model for national medicines inventory system in Indonesia. Due to its complexity, system dynamics approach is used to develop the model. The model describes relationship among government regulation, supplier performance, and health care provider behavior. In the near future the proposed model will be used to evaluate the effectiveness of government regulation on national medicines inventory system.