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Abstract Objective: This study aimed to determine the levels of prostaglandin in patients with primary dysmenorrhea pain. Method: This type of research was quasi-experiment. The sample in this study was 21 people of second-semester students of Midwifery Study Program at Mega Rezky College of Health Sciences (STIKES) Makassar, of which 11 students had moderate primary dysmenorrhea pain, and ten students experienced severe dysmenorrhea pain. Taking blood samples of 3ml through the cubit vein to examine the levels of prostaglandin PGF2α was carried outAbstract Objective: This study aimed to determine the levels of prostaglandin in patients with primary dysmenorrhea pain. Method: This type of research was quasi-experiment. The sample in this study was 21 people of second-semester students of Midwifery Study Program at Mega Rezky College of Health Sciences (STIKES) Makassar, of which 11 students had moderate primary dysmenorrhea pain, and ten students experienced severe dysmenorrhea pain. Taking blood samples of 3ml through the cubit vein to examine the levels of prostaglandin PGF2α was carried out on the first day of menstruation using the Enzyme-Linked Immunosorbent Assay (ELISA) Method, while to assess the pain intensity of primary Dysmenorrhea using the Visual Analogue Scale (VAS). Data analysis used Independent T-Test and Pearson Correlation Test. Results: The results showed that there were significant differences in the mean levels of prostaglandin PGF2 between the moderate primary dysmenorrhea group and the severe primary dysmenorrhea group (p = 0.001). The mean of prostaglandin PGF2α level in the severe primary dysmenorrhea group was higher than the mean of prostaglandin PGF2α level in the moderate primary dysmenorrhea group, and there was a significant correlation between the levels of prostaglandin PGF2α on the intensity of pain in primary dysmenorrhea (p = 0.000). Conclusion: Thus, we can conclude that the greater the pain intensity score, the higher the levels of prostaglandin PGF2α. on the first day of menstruation using the Enzyme-Linked Immunosorbent Assay (ELISA) Method, while to assess the pain intensity of primary Dysmenorrhea using the Visual Analogue Scale (VAS). Data analysis used Independent T-Test and Pearson Correlation Test. Results: The results showed that there were significant differences in the mean levels of prostaglandin PGF2 between the moderate primary dysmenorrhea group and the severe primary dysmenorrhea group (p = 0.001). The mean of prostaglandin PGF2α level in the severe primary dysmenorrhea group was higher than the mean of prostaglandin PGF2α level in the moderate primary dysmenorrhea group, and there was a significant correlation between the levels of prostaglandin PGF2α on the intensity of pain in primary dysmenorrhea (p = 0.000). Conclusion: Thus, we can conclude that the greater the pain intensity score, the higher the levels of prostaglandin PGF2α.