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Brown oyster mushroom is one of the consumption mushrooms with high economic value, so it is important to be cultivated commercially. Several types of plant and industrial wastes, such as dried banana leaves and tofu dregs, are available abundantly in the field. The waste has the potential to be used as a medium for growing consumption mushrooms. This is because dried banana leaves and tofu dregs contain enough nutrients needed for the growth and development of oyster mushrooms. The study aimed to determine the growth response and yield of brown oyster mushrooms by giving various doses of dried banana leaves and tofu dregs flour. The research was carried out using factorial completely randomized design. Factor I: dosage of tofu flour, consisting of 3 levels, namely: 50, 150, and 250 g / baglog. Factor II: dosage of dried banana leaves, consisting of 3 test levels, namely: without dried banana leaves, 100 g / baglog, and 250 g / baglog. The results showed that the treatment of addition of tofu flour with dried banana leaves interacted very significantly in the number of mushroom hoods, diameter and thickness of the hood, the length of the mycelium, the wet weight of the fungus, and biological efficiency.