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Tender Coconut Water Prevent Lipid Peroxidation and Increase Antioxidant Enzyme on Wistar Rats Induced by Lead
SitiThomas Zulaikhah, Joko Wahyuwibowo

Department of Public Health, Faculty of Medicine, Unissula Semarang


Abstract

Background: Lead (Pb) is one of heavy metal which can trigger the formation of Reactive Oxygen Species (ROS), increase the generation of free radicals, lipid peroxidation and decrease antioxidant enzyme such as glutathion peroxidase (GPx). Tender coconut water contains antioxidants, L-arginine and other compounds that can reduce the effects of Pb exposure. This study aimed to know the effect of tender coconut water prevent lipid peroxidation and increase antioxidant enzyme on Wistar Rats Induced by Lead. Methods: Experimental research by post test only control group design, using 18 white wistar strain male rats randomly divided into 3 groups. Group K1 served as control, Group K2 was fed lead (10 mg/day/rat), Group K3 was given tender coconut water orally for four weeks. Induced by Pb is done by inhalation at the dose of 10 mg/day/head, while tender coconut water is given at the dose of 8 mL/200grBB/day together for 4 weeks. Rats- blood from ophtalmicus venous was analyzed using Elisa to measure the Malondialdehyde (MDA) levels and GPx levels. Data were analyzed using Anova test. Results: Average MDA level in group K2 increase compared to group K1, but K3 descrease compared to K2. Average GPx levels in group K2 descrease compared to group K1, but K3 increase compared to group K2. Conclusion: Results of the present study have administration of tender coconut water (8 mL/200gr BW rats/day for 4 weeks) could descreased MDA levels and increased GPx levels (p <0.05). The administration of tender coconut water prevent lipid peroxidation and increase antioxidant enzyme on wistar rats induced by lead

Keywords: Lead (Pb); tender coconut water; lipid peroxidation, antioxidant enzyme

Topic: Basic and Clinical Medical Sciences

Link: https://ifory.id/abstract/gFEPMWu6xGXH

Conference: Medical and Global Health Research Symposium (MORES 2019)

Plain Format | Corresponding Author (Siti Thomas Zulaikhah)

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