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Potential of Aloe Vera for Treatment of infection with Aeromonas hydrophila bacteria on Koi Fry Rosidah1, Angga Nugraha 2, Yuli Andriani3 and Kiki Haetami 4 1,3,4Departement of Fisheries, Faculty of Fisheries and Marine Science Universitas Padjadjaran Indonesia (Email : ros_ahdi@yahoo.com, yuliyusep@yahoo.com, kiki.haetami@gmail.com) 2Fisheries Student, Faculty of Fisheries and Marine Science, Universitas Padjadjaran; Indonesia (E-mail : angganugraha5043@gmail.com) ABSTRACT Alternative medicine to treat Motile Aeromonas Septicemia is one of them is aloe vera extract. This research has been carried out at Aquaculture laboratory and Biotechnology Laboratory of the faculty of Fisheries and Marine Science, Padjadjaran University. Research began from March 2019 to April 2019.This study aims to study the ability of aloe vera extract to treat koi fry which is attacked by A. hydrophila bacteria. The method used is the experimental method using a completely randomized design (CRD) with five treatments and three replications. The treatment used was immersion with aloe vera extract with a concentration of treatment A (0 ppm), B (150 ppm), C (300 ppm), D (450 ppm) and E (600 ppm). The parameters observed were clinical symptoms which included damage to fish body, fish feeding response and fish response to surprises which were analyzed descriptively comparatively. The results showed that the use of aloe vera extract with a concentration of 300 ppm for 48 hours was effective to treat koi fry infected with Aeromonas hydrophila by healing relatively fast body damage, response to feed and fast and normal fast shock.