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Aim: To prove that Moringa Oleifera leaves extract can reduce the number of VEGF expression in oral cancer cells of Benzopyrene-induced wistar Rats. Method:This is an experimental laboratory research with post test only control group design.All experimental animals were made under the condition of cancer with benzopyrene induction of 8mg/kgBW.The sample consisted of 28 wistar Rats were devided into 4 groups namely : control group(K), which was only given aquades and the treatment group (P1) treated with leave extract Moringa Oleifera of 3,125.,(P2) with 4,6875%.,(P3) with 6,25%. Observation of VEGF expression with Immunohistochemical staining. Result: Decrease in VEGF difference between the control group (K) and the treatment group (P1), but there were no significant differences among treatment groups (P1, P2,P3). The higest decrease of VEGF expression was 3,125% (P1). Conclusion: Moringa Oleifera Leaves extract 3,125% is the best for decreasing VEGF expression in wistar Rats oral cancer celss.