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DESIGN AND DEVELOPMENT OF PEEL-OFF MASK GEL FORMULATION OF CITRONELLA OIL FOR ACNE VULGARIS
Dyah Rahmasari, Dian Ermawati, Raditya Weka Nugraheni, Dwi Ramadhaningtyas Putri, Indah Nur Pratiwi

Universitas Muhammadiyah Malang


Abstract

Background: Cymbopogon nardus is a traditional plant that has chemical content of citronella oil with potential antibacterial activity. Antibacterial peel-off mask is very easy to applicate on face. Objective: This research aim is to develop and characterize the antibacterial peel-off mask gel containing citronella oil. Method: This study used an experimental method. The peel-off mask was formulated using 8%, 10%, and 12% of polyvinyl alcohol (PVA) as a gelling agent. Evaluation of peel-off mask including physical characteristics (organoleptic, homogeneity, viscosity, spreadability, film drying time), chemical characteristic (pH value), stability and antibacterial activity. Result: The organoleptic properties showed that the citronella oil peel-off gel mask was white, aromatic and had a soft texture. The variation in PVA affects the pH value, viscosity and film drying time of the peel-off mask, significantly. Stability test showed that all peel-off mask was no significant changes physically in the freeze-thaw method, but there was some color change and phase separation in the real-time method. The peel-off mask containing citronella oil using 8% PVA has the highest inhibition against Propionibacterium acnes almost the same with the positive control (clindamycin gel). Conclusion: Variation concentration of PVA in the formula was affected on the physical and chemical characteristics and antibacterial activity of the citronella oil peel-off mask gel, significantly. The preparation using 8% PVA gives the best formula with optimal results.

Keywords: citronella oil; peel off mask gel; stability; antibacterial activity

Topic: Pharmaceutical Science

Link: https://ifory.id/abstract/j9hwGLTEzdKX

Conference: The 2nd Health Science International Conference (HSIC 2019)

Plain Format | Corresponding Author (Dyah Rahmasari)

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