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EXTRACT GEL OF CHINESE PETAI LEAF (LEUCAENALEUCOCEPHALA) FOR ACUTE WOUNDS IN RATS (RATTUSNORVEGICUS)
Anis Ika Nur Rohmah, Edi Purwanto, Viky Nurdiansyah

University of Muhammadiyah Malang


Abstract

Introduction: The many occurrences of acute injuries due to the surgical process or accident have a considerable risk of complications if not given appropriately. Chinese Petaileaves contains saponins, tannins, and flavonoids are useful for accelerating through the process of acute wound healing. Saponins, tannins, and flavonoids had a certain function as antibacterial, antioxidant and can protect collagen which could inhibit bacterial growth, prevent infection and it also accelerates some epithelialization process effectively. Moreover, Chinese Petaileaves were easy to get and cheap. In this study, extract Chinese Petai leaf made in gel preparations to be practical, sterile, and become the latest innovation. The purpose of this study is to make the latest innovations and proved the extract gel Chinese Petai leaf effectively for the treatment of acute wounds to rats. Research Methods: Using true-experimental design with a randomized control group posttest design as an approach in this study. The experimental design was done randomly to select rats, intervention group (n = 7) and control group (n = 6) used simple random sampling. Statistical analysis of differences in the percentage of wound closure in this study used Man Whitney test. Results: The results of the statistical test analysis indicated that the first group (Extract Gel Chinese Petai Leaf) and the second group (Normal Saline) had significant differences in the percentage of wound closure on the eighth day with the score (p = 0.014) using SPSS 16.0 statistical test. Discussion: Difference in the percentage of wound closure was seen starting early in the epithelialization phase of acute wounds and more clearly on the eighth day. This is due to the contains of saponins, tannins, and flavanoids in extract gel of Chinese Petai leaf. Conclusion: Extract gel of Chinese Petai leaf effectively accelerated the closure of wound acute stage II. The gel can immediately fill the wound area so that the active components of Chinese Petai leaves is quickly absorbed by the skin.

Keywords: Chinese Petai Leaf, Acute Wounds, Rats

Topic: Medical and Surgical

Link: https://ifory.id/abstract/jQ2tgTx7wBNb

Conference: The 2nd Health Science International Conference (HSIC 2019)

Plain Format | Corresponding Author (Anis Ika Nur Rohmah)

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